2. University of Uppsala (UU)
Partner Leaders : Mats Nilsson / Ulf Landegren
UU will coordinate the workpackage on "New genotyping challenges" and will develop methods for multiplex preparation of targeted loci for 2nd generation sequencing technology, and multiplexed targeted methylation assays. We will further apply a single-molecule detection approach for highly precise digital quantification of copy-number variation in a format suitable for automation and clinical diagnostics. The single-molecule detection approach can also be applied for localized analysis, enabling genotyping of single-cells in the preserved context of tissue sections.